Revealing the mechanisms of protein disorder and N-glycosylation in CD44-hyaluronan binding using molecular simulation
The extracellular N-terminal hyaluronan binding domain (HABD) of CD44 is a small globular domain that confers hyaluronan (HA) binding functionality to this large transmembrane glycoprotein.When recombinantly expressed by itself, HABD exists as a globular water-soluble protein that retains the capacity to bind HA.This has enabled atomic-resolution s